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Welcome to Gui Lab
Cutting-edge research in Molecular and Structural Biology
Targeting biomolecular condensation and protein aggregation against cancer
About The Cover:
Liquid–liquid phase separation and solid-like oligomers and aggregates of the p53 tumor suppressor are related to cancer phenotypes and represent novel targets for anticancer therapy. Shown here are p53 condensates and 16-mer p53 oligomers embracing DNA. Drugs lead to either p53 droplet dissolution or the clearance of p53 aggregates.
Check the whole story in our
Chemical Review paper:
https://pubs.acs.org/doi/10.1021/acs.chemrev.3c00131
Cancer Threat in a Drop
On The Cover:
Cancer Threat in a Drop!
Check the whole story in our
Chemical Science paper:
"Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands"
https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc01739j#!divAbstract
Frustration Networks in Troponin C
On The Cover:
Frustration Networks in Troponin C
Check the whole story in our
Chemical Science paper:
"Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy" by Marques et al.
2021.
Check at
https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc01886h#!divAbstract
Check the whole story in our JBC paper:
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"Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion​​" by Marques MA. et al. 2017 292(6):2379-2394
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This work was selected to appear in a special virtual issue on structural biology at the JBC. Editors looked through hundreds of papers to come up with what they felt best represented the exciting advances made in structural biology over the last three years.
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Check at
http://www.jbc.org/site/vi/structbio/
On The Cover:
Myristoylated c-Abl (green) colocalizes (cyan) with the plasma membrane.
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Check the whole story in our JBC paper:
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"Intramolecular dynamics within the N-SH3-SH2 regulatory unit of the c-Abl Tyrosine kinase reveal targeting to the cellular membrane" by de Oliveira GA et al. 2013 288(39):28331-28345
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This work was selected "Paper of the Week", appeared on the Cover issue, and Dr. de Oliveira received an Author profile at JBC.
Check at
http://www.jbc.org/content/288/39/28346/suppl/DCAuthor_profile
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