- 2023 -
Chemical Reviews
Targeting biomolecular condensation and protein aggregation against cancer
Jerson L. Silva, Debora Foguel, Vitor F. Ferreira, Tuane C. R. G. Vieira, Mayra A. Marques, Giulia D. S. Ferretti, Tiago F. Outeiro, Yraima Cordeiro, and Guilherme A. P. de Oliveira
iScience
Conformational stability of SARS-CoV-2 glycoprotein spike variants
Hiam R.S. Arruda, Tulio M. Lima, Renata G.F. Alvim,
Fernanda B.A. Victorio, Daniel P.B. Abreu, Federico F. Marsili, Karen D. Cruz, Mayra A. Marques, Patricia Sosa-Acosta, Mauricio Quinones-Vega, Jéssica de S. Guedes, Fábio C.S. Nogueira, Jerson L. Silva, Leda R. Castilho,
and Guilherme A.P. de Oliveira
Biochemistry
Water Leakage Pathway Leads to Internal Hydration of the p53 Core Domain
Igor D. M. Lima, Murilo M. Pedrote, Mayra A. Marques, Gileno dos S. de Sousa, Jerson L. Silva, Guilherme A. P. de Oliveira, and Elio A. Cino
- 2022 -
Current Opinion in Sctructural Biology
Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation
Jerson L. Silva, Tuane C. Vieira, Yraima Cordeiro and
Guilherme A. P. de Oliveira
The Journal of Physical
Chemistry B
Evolutionary Role of Water-Accessible Cavities in Src Homology 2 (SH2) Domains
Guilherme A. P. de Oliveira, Hiam R. S. Arruda,
Guilherme C. de Andrade, and Jerson L. Silva
Essays in Biochemistry
The chameleonic behavior of p53 in health and
disease: the transition from a client to an aberrant condensate scaffold in cancer
Mayra A. Marques, Guilherme A.P. de Oliveira and
Jerson L. Silva
Frontiers in Molecular Biosciences
Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53
Mayra A. Marques, Guilherme C. de Andrade, Jerson L. Silva
and Guilherme A. P. de Oliveira
- 2021 -
Chemical Science
Anomalous structural dynamics of minimally
frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy
Mayra A. Marques, Maicon Landim-Vieira, Adolfo H. Moraes, Bin Sun, Jamie R. Johnston, Karissa M. Dieseldorff Jones, Elio A. Cino, Michelle S. Parvatiyar, Isela C. Valera, Jerson L. Silva, Vitold E. Galkin, P. Bryant Chase, Peter M. Kekenes-Huskey,
Guilherme A. P. de Oliveira, and Jose Renato Pinto
Chemical Science
Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands
Elaine C. Petronilho, Murilo M. Pedrote, Mayra A. Marques,
Yulli M. Passos, Michelle F. Mota, Benjamin Jakobus, Gileno dos Santos de Sousa, Filipe Pereira da Costa, Adriani L. Felix, Giulia D. S. Ferretti, Fernando P. Almeida, Yraima Cordeiro, Tuane C. R. G. Vieira, Guilherme A. P. de Oliveira and
Jerson L. Silva
Current Opinion in Virology
Cryo-EM to visualize the structural organization of viruses
Guilherme A P de Oliveira and Jerson L Silva
Biotechnology and
Bioengineering
Process intensification for the production of yellow fever virus‐like particles as potential recombinant vaccine antigen
Renata G. F. Alvim, Túlio M. Lima, Jerson L. Silva,
Guilherme A. P. de Oliveira, and Leda R. Castilho
Biophysical Chemistry
Exploring the polymorphism, conformational dynamics and function of amyloidogenic peptides and proteins by temperature and pressure modulation
Lena Ostermeier, Guilherme A. P. de Oliveira, Wojciech Dzwolak, Jerson L. Silva, Roland Winter
- 2020 -
1. Biophysical characterization of p53 core domain aggregates. Biochem J, 477(1): 111-120
2. Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers. iScience, 23(2): 100820
3. The Status of p53 Oligomeric and Aggregation States in Cancer. Biomolecules, 10(4): 548
4. Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi
J Struct Biol, 211(2): 107536
- 2019 -
1. High pressure studies on the misfolding and aggregation of p53 in cancer and of α-synuclein in Parkinson's disease.
High Pressure Research, 39: 1-9
2. Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma
cells. J Biol Chem, 294(24): 9430-9439
3. An extensively glycosylated archaeal pilus survives extreme conditions. Nature Microbiology, 4(8): 1401-1410
4. New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents.
Molecules, 24(11)
5. Conformational isomerization involving conserved proline residues modulates oligomerization of the NS1 interferon response inhibitor from the syncytial respiratory virus. Biochemistry, 58(26): 2883-2892
6. A conformational switch balances viral RNA accessibility and protection in a nucleocapsid ring model.
Arch Biochem Biophys, 671: 77-86
7. Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease.
Commun Biol, 2: 374
8. A packing for A-form DNA in an icosahedral virus. Proc Natl Acad Sci USA, 116(45): 22591-22597
9. Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases.
Adv Protein Chem Struct Biol, 118: 289-331
10. The intrinsically disordered carboxy-terminus of troponin-T binds to troponin-C to modulate myocardial force generation. J Biol Chem, 294(52): 20054-20069
11. The missing links within troponin. Arch Biochem Biophys, 663: 95-100
- 2018 -
1. Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer. J Biol Chem, 293(29): 11374-11387
2. Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer. Acc Chem Res, 51(1):181-190
- 2017 -
1. Allosteric transmission along a loosely structured backbone allows a cardiac Troponin C mutant to function with only one Ca2+ ion. J Biol Chem, 292(6): 2379-2394
2. Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C. Sci Rep, 7(1): 691
3. The push-and-pull hypothesis in protein unfolding, misfolding and aggregation. Biophys Chem, 231: 20-26
4. Interactions of ruthenium(II) compounds with sulfasalazine and N,N′-heterocyclic ligands with proteins. Inorganica Chim Acta, 467: 385-390
- 2016 -
1. Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?
Cold Spring Harb Perspect Biol, 8(10)
2. Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds. Sci Rep, 6: 32535
3. Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy
Phenotype. Front Physiol, 7: 429
4. Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core.
Sci Rep, 6: 37990
- 2015 -
1. A hypothesis to reconcile the physical and chemical unfolding of proteins. Proc Natl Acad Sci USA, 112(21): E2775-84
2. Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer. Front Oncol, 5: 97
3. The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role Against α-Synuclein Oligomers. J Biol Chem, 290(33): 20527-40
- 2014 -
1. High-pressure chemical biology and biotechnology. Chem Rev, 114(14): 7239-67
2. Solution and high-pressure NMR studies of the structure, dynamics and stability of the cross-reactive allergenic cod parvalbumin Gad m 1. Proteins, 82(11): 3032-42
- 2013 -
1. Insights into the Intramolecular Coupling between the N- and C-Domains of Troponin C Derived from High-Pressure, Fluorescence, Nuclear Magnetic Resonance, and Small-Angle X-ray Scattering Studies. Biochemistry, 52(1): 28-40
2. Nep1-like protein from Moniliophthora perniciosa induces a rapid proteome and metabolome reprogramming in cells of Nicotiana benthamiana. Physiol Plant, 150(1): 1-17
3. Full Inactivation of Human Influenza Virus by High Hydrostatic Pressure Preserves Virus Structure and Membrane Fusion While Conferring Protection to Mice against Infection. Plos One, 8(11): e80785
4. Fine Modulation of the Respiratory Syncytial Virus M2-1 Protein Quaternary Structure by Reversible Zinc Removal from its Cys3-His1 Motif. Biochemistry, 52(39): 6779-89
5. Intramolecular Dynamics within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane. J Biol Chem, 288(39): 28331-45
- 2012 -
1. Metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 are increased in vulvar lichen sclerosus. Eur J Obstet Gynecol Reprod Biol, 161(1): 96-101
2. Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: Implications for cancer. J Biol Chem, 287(33): 28152-62
3. Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications. Plos One, 7(9): e45620
- 2010 -
1. Positive response to imatinib mesylate therapy for childhood chronic myeloid leukemia. Braz J Med Biol Res, 43(6): 580-4
- 2009 -
1. Expression of metalloproteinases and their tissue inhibitors in gingiva affected by hereditary gingival fibromatosis: analysis of three cases within a family. J Periodontal Res, 44(6): 714-7
- 2008 -
1. Expression of metalloproteinases and their tissue inhibitors in inflamed gingival biopsies. J Periodontal Res, 43(5): 570-7
